Immunogenomic analytical approaches for research and clinical applications

Sachet Shukla

Immunogenomic analytical approaches for research and clinical applications

One of the critical steps to developing curative and tumor-specific immunotherapies is the identification and selection of antigens with tumor-restricted expression in order to avoid undesirable immune responses against normal tissues. Proteins with tumor-specific mutations have the potential to be the most restricted of all tumor antigens. However, the comprehensive identification of such `neoantigens’ has

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